Tropical Diseases: Translating Discoveries Into Better Health

Systems approach identifies monocyte imbalance in symptomatic and asymptomatic P. vivax malaria

SI Studniberg, M Bafit, LJ Ioannidis, MJ Worley, L Trianty, RAS Utami, AM Puspitasari, D Apriyanti, FN Coutrier, JR Poespoprodjo, E Kenangalem, B Andries, P Prayoga, RN Price, R Noviyanti, AL Garnham, DS Hansen

2025-11-03

Although asymptomatic malaria was historically perceived as innocuous, emerging evidence revealed an immunosuppressive signature i..

Tfh2 and a subset of Tfh1 cells associate with antibody-mediated immunity to malaria

MSF Soon, DA Oyong, NL Dooley, R Mukhiya, Z Pava, DW Andrew, JR Loughland, JS McCarthy, JA Chan, JG Beeson, CR Engwerda, A Haque, MJ Boyle

2025-01-01

High-affinity antibody production depends on CD4⁺ T follicular helper (Tfh) cells. In humans, peripheral blood Tfh cell..

Heterogeneity of the human immune response to malaria infection and vaccination driven by latent cytomegalovirus infection

Reena Mukhiya, Wim A Fleischmann, Jessica R Loughland, Jo-Anne Chan, Fabian de Labastida Rivera, Dean Andrew, James G Beeson, James S McCarthy, Bridget E Barber, J Alejandro Lopez, Christian Engwerda, Richard Thomson-Luque, Michelle J Boyle

2024-11-01

BACKGROUND: Human immune responses to infection and vaccination are heterogenous, driven by multiple factors including genetics, e..

Primaquine radical cure in patients with Plasmodium falciparum malaria in areas co-endemic for P falciparum and Plasmodium vivax (PRIMA): a multicentre, open-label, superiority randomised controlled trial

K Thriemer, TS Degaga, M Christian, MS Alam, M Rajasekhar, B Ley, MS Hossain, MG Kibria, TT Tego, DT Abate, S Weston, H Mnjala, A Rumaseb, AW Satyagraha, A Sadhewa, LV Panggalo, LL Ekawati, G Lee, RT Anose, FG Kiros

2023-12-02

Background: In areas co-endemic for Plasmodium vivax and Plasmodium falciparum there is an increased risk of P vivax parasitaemia ..

A CAF01-adjuvanted whole asexual blood-stage liposomal malaria vaccine induces a CD4 T-cell-dependent strain-transcending protective immunity in rodent models

WA Okoth, MF Ho, M Zaman, E Cooper, P Som, M Burgess, M Walton, RJ Nevagi, L Beattie, D Murphy, DI Stanisic, MF Good

2023-12-01

Malaria is a leading cause of illness and death in children under 5 years of age in Sub-Saharan Africa. Currently, there is no hig..

A model for malaria treatment evaluation in the presence of multiple species

CR Walker, RI Hickson, E Chang, P Ngor, S Sovannaroth, JA Simpson, DJ Price, JM McCaw, RN Price, JA Flegg, A Devine

2023-09-01

Plasmodium falciparum and P. vivax are the two most common causes of malaria. While the majority of deaths and severe morbidity ar..

Sting activation promotes autologous type i interferon–dependent development of type 1 regulatory t cells during malaria

Y Wang, F De Labastida Rivera, CL Edwards, TCM Frame, JA Engel, L Bukali, J Na, SS Ng, D Corvino, MM De Oca, PT Bunn, MSF Soon, D Andrew, JR Loughland, J Zhang, FH Amante, BE Barber, JS McCarthy, JA Lopez, MJ Boyle

2023-08-15

The development of highly effective malaria vaccines and improvement of drug-treatment protocols to boost antiparasitic immunity a..

Adapting international clinical trials during COVID-19 and beyond

K Thriemer, TS Degaga, MS Alam, B Adhikari, R Tripura, MS Hossain, M Christian, NK Ghanchi, H Mnjala, S Weston, B Ley, A Rumaseb, D Tadesse, T Teferi, D Yilma, G Lee, H Unger, I Sutanto, AP Pasaribu, P Ghimire

2023-06-01

Background: The COVID-19 pandemic and resulting restrictions, particularly travel restrictions, have had significant impact on the..

Human IL-10–producing Th1 cells exhibit a molecular signature distinct from Tr1 cells in malaria

CL Edwards, SS Ng, F de Labastida Rivera, D Corvino, JA Engel, MM de Oca, L Bukali, TCM Frame, PT Bunn, SB Chauhan, SS Singh, Y Wang, J Na, FH Amante, JR Loughland, MSF Soon, N Waddell, P Mukhopadhay, LT Koufariotis, RL Johnston

2023-01-03

Control of intracellular parasites responsible for malaria requires host IFN-γ⁺T-bet⁺CD4⁺ T cells..

Positron emission tomography and magnetic resonance imaging of the brain in experimental human malaria, a prospective cohort study

J Woodford, A Gillman, P Jenvey, J Roberts, S Woolley, BE Barber, M Fernandez, S Rose, P Thomas, NM Anstey, JS McCarthy

2022-12-01

Cerebral malaria is the most serious manifestation of severe falciparum malaria. Sequestration of infected red blood cells and mic..

Reducing the risk of Plasmodium vivax after falciparum infections in co-endemic areas—a randomized controlled trial (PRIMA)

K Thriemer, TS Degaga, M Christian, MS Alam, B Ley, MS Hossain, MG Kibria, TT Tego, DT Abate, S Weston, A Karahalios, M Rajasekhar, JA Simpson, A Rumaseb, H Mnjala, G Lee, RT Anose, FG Kidane, A Woyessa, K Baird

2022-12-01

Background: Plasmodium vivax forms dormant liver stages that can reactivate weeks or months following an acute infection. Recurren..

The in-vivo dynamics of Plasmodium falciparum HRP2: implications for the use of rapid diagnostic tests in malaria elimination

L Marquart, L Webb, P O’Rourke, ML Gatton, MS Hsiang, M Kalnoky, IK Jang, H Ntuku, DR Mumbengegwi, GJ Domingo, JS McCarthy, S Britton

2022-12-01

Background: Rapid diagnostic tests (RDTs) that rely on the detection of Plasmodium falciparum histidine-rich protein 2 (PfHRP2) ha..

Longitudinal IgG antibody responses to Plasmodium vivax blood-stage antigens during and after acute vivax malaria in individuals living in the Brazilian Amazon

T Tashi, A Upadhye, P Kundu, C Wu, S Menant, RR Soares, MU Ferreira, RJ Longley, I Mueller, QQ Hoang, WH Tham, JC Rayner, KKG Scopel, JC Lima-Junior, TM Tran

2022-11-01

Background To make progress towards malaria elimination, a highly effective vaccine targeting Plasmo-dium vivax is urgently needed..

Assessment of IgG3 as a serological exposure marker for Plasmodium vivax in areas with moderate–high malaria transmission intensity

Y Tayipto, J Rosado, D Gamboa, MT White, B Kiniboro, J Healer, DH Opi, JG Beeson, E Takashima, T Tsuboi, M Harbers, L Robinson, I Mueller, RJ Longley

2022-08-09

A more sensitive surveillance tool is needed to identify Plasmodium vivax infections for treatment and to accelerate malaria elimi..

Plasmodium vivax malaria serological exposure markers: Assessing the degree and implications of cross-reactivity with P. knowlesi

RJ Longley, MJ Grigg, K Schoffer, T Obadia, S Hyslop, KA Piera, N Nekkab, R Mazhari, E Takashima, T Tsuboi, M Harbers, K Tetteh, C Drakeley, CE Chitnis, J Healer, WH Tham, J Sattabongkot, MT White, DJ Cooper, GS Rajahram

2022-06-21

Serological markers are a promising tool for surveillance and targeted interventions for Plasmodium vivax malaria. P. vivax is clo..

Scoping Review of Antimalarial Drug Candidates in Phase I and II Drug Development

AN Abd-Rahman, S Zaloumis, JS McCarthy, JA Simpson, RJ Commons

2022-02-01

The emergence and spread of parasite resistance to currently available antimalarials has highlighted the importance of developing ..

Adults with Plasmodium falciparum malaria have higher magnitude and quality of circulating T-follicular helper cells compared to children

DA Oyong, JR Loughland, MSF Soon, JA Chan, D Andrew, BD Wines, PM Hogarth, SD Olver, AD Collinge, A Varelias, JG Beeson, E Kenangalem, RN Price, NM Anstey, G Minigo, MJ Boyle

2022-01-01

Background: Protective malarial antibodies are acquired more rapidly in adults than children, independently of cumulative exposure..

Analytical validation of a real-time hydrolysis probe PCR assay for quantifying Plasmodium falciparum parasites in experimentally infected human adults

CYT Wang, EL Ballard, Z Pava, L Marquart, J Gaydon, SC Murphy, D Whiley, P O’Rourke, JS McCarthy

2021-12-01

Background: Volunteer infection studies have become a standard model for evaluating drug efficacy against Plasmodium infections. M..

Development and evaluation of a new Plasmodium falciparum 3D7 blood stage malaria cell bank for use in malaria volunteer infection studies

SD Woolley, M Fernandez, M Rebelo, SA Llewellyn, L Marquart, FH Amante, HE Jennings, R Webster, K Trenholme, S Chalon, JJ Moehrle, JS McCarthy, BE Barber

2021-12-01

Background: New anti-malarial therapeutics are required to counter the threat of increasing drug resistance. Malaria volunteer inf..

Haematological response in experimental human Plasmodium falciparum and Plasmodium vivax malaria

SD Woolley, L Marquart, J Woodford, S Chalon, JJ Moehrle, JS McCarthy, BE Barber

2021-12-01

Background: Malaria-associated anaemia, arising from symptomatic, asymptomatic and submicroscopic infections, is a significant cau..

Reduced circulating dendritic cells in acute Plasmodium knowlesi and Plasmodium falciparum malaria despite elevated plasma Flt3 ligand levels

JR Loughland, T Woodberry, D Oyong, KA Piera, FH Amante, BE Barber, MJ Grigg, T William, CR Engwerda, NM Anstey, JS McCarthy, MJ Boyle, G Minigo

2021-12-01

Background: Plasmodium falciparum malaria increases plasma levels of the cytokine Fms-like tyrosine kinase 3 ligand (Flt3L), a hae..

Safety and feasibility of apheresis to harvest and concentrate parasites from subjects with induced blood stage Plasmodium vivax infection

A Odedra, K Mudie, G Kennedy, RE Watts, E Rossignol, H Mitchell, J Gower, M Rebelo, Z Pava, R Pawliw, S Woolley, DG Lalloo, G Robinson, S Lynch, KA Collins, F Amante, J McCarthy

2021-12-01

Background: In the absence of a method to culture Plasmodium vivax, the only way to source parasites is ex vivo. This hampers many..

Safety, infectivity and immunogenicity of a genetically attenuated blood-stage malaria vaccine

R Webster, S Sekuloski, A Odedra, S Woolley, H Jennings, F Amante, KR Trenholme, J Healer, AF Cowman, EM Eriksson, P Sathe, J Penington, AJ Blanch, MWA Dixon, L Tilley, MF Duffy, A Craig, J Storm, JA Chan, K Evans

2021-12-01

Background: There is a clear need for novel approaches to malaria vaccine development. We aimed to develop a genetically attenuate..

Systems serology detects functionally distinct coronavirus antibody features in children and elderly

KJ Selva, CE van de Sandt, MM Lemke, CY Lee, SK Shoffner, BY Chua, SK Davis, THO Nguyen, LC Rowntree, L Hensen, M Koutsakos, CY Wong, F Mordant, DC Jackson, KL Flanagan, J Crowe, S Tosif, MR Neeland, P Sutton, PV Licciardi

2021-12-01

The hallmarks of COVID-19 are higher pathogenicity and mortality in the elderly compared to children. Examining baseline SARS-CoV-..

Vaccination of human participants with attenuated Necator americanus hookworm larvae and human challenge in Australia: a dose-finding study and randomised, placebo-controlled, phase 1 trial

PR Chapman, R Webster, P Giacomin, S Llewellyn, L Becker, MS Pearson, F De Labastida Rivera, P O'Rourke, CR Engwerda, A Loukas, JS McCarthy

2021-12-01

Background: Control of human hookworm infection would be greatly aided by the development of an effective vaccine. We aimed to dev..

Poly(hydrophobic amino acid) Conjugates for the Delivery of Multiepitope Vaccine against Group A Streptococcus

Armira Azuar, Mohini A Shibu, Nomin Adilbish, Nirmal Marasini, Hong Hung, Jieru Yang, Yacheng Luo, Zeinab G Khalil, Robert J Capon, Waleed M Hussein, Istvan Toth, Mariusz Skwarczynski

2021-11-17

Peptide-based vaccines are composed of small, defined, antigenic peptide epitopes. They are designed to induce well-controlled imm..

Seeking an optimal dosing regimen for OZ439/DSM265 combination therapy for treating uncomplicated falciparum malaria

S Dini, SG Zaloumis, DJ Price, N Gobeau, A Kümmel, M Cherkaoui, JJ Moehrle, JS McCarthy, JA Simpson

2021-09-01

Background: The efficacy of artemisinin-based combination therapies (ACTs), the first-line treatments for uncomplicated falciparum..

Reply to White and Watson

M Rebelo, JS McCarthy, DS Khoury

2021-08-15

Parasite Viability as a Superior Measure of Antimalarial Drug Activity in Humans

M Rebelo, R Pawliw, J Gower, L Webb, H Mitchell, Z Pava, RE Watts, MP Davenport, JS McCarthy, DS Khoury

2021-06-15

Background: Artemisinin derivatives are the leading class of antimalarial drugs due to their rapid onset of action and rapid clear..

Pre-clinical evaluation of a whole-parasite vaccine to control human babesiosis

HA Al-Nazal, E Cooper, MF Ho, S Eskandari, V Majam, AK Giddam, WM Hussein, MT Islam, M Skwarczynski, I Toth, S Kumar, A Zaid, M Batzloff, DI Stanisic, MF Good

2021-06-09

Babesia spp. are tick-transmitted intra-erythrocytic protozoan parasites that infect humans and animals, causing a flu-like illnes..

CD8 T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity

THO Nguyen, LC Rowntree, J Petersen, BY Chua, L Hensen, L Kedzierski, CE van de Sandt, P Chaurasia, HX Tan, JR Habel, W Zhang, LF Allen, L Earnest, KY Mak, JA Juno, K Wragg, FL Mordant, F Amanat, F Krammer, NA Mifsud

2021-05-11

To better understand primary and recall T cell responses during coronavirus disease 2019 (COVID-19), it is important to examine un..

Positron emission tomography and magnetic resonance imaging in experimental human malaria to identify organ-specific changes in morphology and glucose metabolism: A prospective cohort study

J Woodford, A Gillman, P Jenvey, J Roberts, S Woolley, BE Barber, M Fernandez, S Rose, P Thomas, NM Anstey, JS McCarthy

2021-05-01

Background Plasmodium vivax has been proposed to infect and replicate in the human spleen and bone marrow. Compared to Plasmodium ..

Integrated immune dynamics define correlates of COVID-19 severity and antibody responses

M Koutsakos, LC Rowntree, L Hensen, BY Chua, CE van de Sandt, JR Habel, W Zhang, X Jia, L Kedzierski, TM Ashhurst, GH Putri, F Marsh-Wakefield, MN Read, DN Edwards, EB Clemens, CY Wong, FL Mordant, JA Juno, F Amanat, J Audsley

2021-03-16

SARS-CoV-2 causes a spectrum of COVID-19 disease, the immunological basis of which remains ill defined. We analyzed 85 SARS-CoV-2-..

Poly(hydrophobic amino acid)-Based Self-Adjuvanting Nanoparticles for Group A Streptococcus Vaccine Delivery

Armira Azuar, Zhuoqing Li, Mohini A Shibu, Lili Zhao, Yacheng Luo, Ahmed O Shalash, Zeinab G Khalil, Robert J Capon, Waleed M Hussein, Istvan Toth, Mariusz Skwarczynski

2021-03-11

Peptide antigens have been widely used in the development of vaccines, especially for those against autoimmunity-inducing pathogen..

Robust correlations across six SARS-CoV-2 serology assays detecting distinct antibody features

LC Rowntree, BY Chua, S Nicholson, M Koutsakos, L Hensen, C Douros, K Selva, FL Mordant, CY Wong, JR Habel, W Zhang, X Jia, L Allen, DL Doolan, DC Jackson, AK Wheatley, SJ Kent, F Amanat, F Krammer, K Subbarao

2021-01-01

Objectives: As the world transitions into a new era of the COVID-19 pandemic in which vaccines become available, there is an incre..

Th2-like T Follicular Helper Cells Promote Functional Antibody Production during Plasmodium falciparum Infection

JA Chan, JR Loughland, F de Labastida Rivera, A SheelaNair, DW Andrew, NL Dooley, BD Wines, FH Amante, L Webb, PM Hogarth, JS McCarthy, JG Beeson, CR Engwerda, MJ Boyle

2020-12-22

CD4⁺ T follicular helper cells (Tfh) are key drivers of antibody development. During Plasmodium falciparum malaria in c..

Liver Function Test Abnormalities in Experimental and Clinical Plasmodium vivax Infection

Anand Odedra, Lachlan Webb, Louise Marquart, Laurence J Britton, Stephan Chalon, Joerg J Moehrle, Nicholas M Anstey, Timothy William, Matthew J Grigg, David G Lalloo, Bridget E Barber, James S McCarthy

2020-11-01

Liver transaminase elevations after treatment in malaria volunteer infection studies (VISs) have raised safety concerns. We invest..

The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation

SS Ng, F De Labastida Rivera, J Yan, D Corvino, I Das, P Zhang, R Kuns, SB Chauhan, J Hou, XY Li, TCM Frame, BA McEnroe, E Moore, J Na, JA Engel, MSF Soon, B Singh, AJ Kueh, MJ Herold, M Montes de Oca

2020-10-01

Immune-modulating therapies have revolutionized the treatment of chronic diseases, particularly cancer. However, their success is ..

Suboptimal SARS-CoV-2−specific CD8 T cell response associated with the prominent HLA-A*02:01 phenotype

JR Habel, THO Nguyen, CE van de Sandt, JA Juno, P Chaurasia, K Wragg, M Koutsakos, L Hensen, X Jia, B Chua, W Zhang, HX Tan, KL Flanagan, DL Doolan, J Torresi, W Chen, LM Wakim, AC Cheng, PC Doherty, J Petersen

2020-09-29

An improved understanding of human T cell-mediated immunity in COVID-19 is important for optimizing therapeutic and vaccine strate..

Safety, tolerability, pharmacokinetics, and antimalarial efficacy of a novel Plasmodium falciparum ATP4 inhibitor SJ733: a first-in-human and induced blood-stage malaria phase 1a/b trial

Aditya H Gaur, James S McCarthy, John C Panetta, Ronald H Dallas, John Woodford, Li Tang, Amber M Smith, Tracy B Stewart, Kristen C Branum, Burgess B Freeman, Nehali D Patel, Elizabeth John, Stephan Chalon, Shelley Ost, Ryan N Heine, Julie L Richardson, Robbin Christensen, Patricia M Flynn, Yvonne Van Gessel, Branko Mitasev

2020-08-01

Background: (+)-SJ000557733 (SJ733) is a novel, orally bioavailable inhibitor of Plasmodium falciparum ATP4. In this first-in-huma..

Assays for quantification of male and female gametocytes in human blood by qRT-PCR in the absence of pure sex-specific gametocyte standards

Claire YT Wang, Emma Ballard, Stacey Llewellyn, Louise Marquart, Teun Bousema, James S McCarthy, Katharine A Collins

2020-06-23

Background Malaria transmission from humans to Anopheles mosquitoes requires the presence of gametocytes in human peripheral circu..

A Plasmodium vivax experimental human infection model for evaluating efficacy of interventions

Katharine A Collins, Claire YT Wang, Matthew Adams, Hayley Mitchell, Greg J Robinson, Melanie Rampton, Suzanne Elliott, Anand Odedra, David Khoury, Emma Ballard, Todd B Shelper, Leonardo Lucantoni, Vicky M Avery, Stephan Chalon, Joerg J Moehrle, James S McCarthy

2020-06-01

BACKGROUND. Interventions that interrupt Plasmodium vivax transmission or eliminate dormant P. vivax liver-stage parasites will be..

Infection-induced plasmablasts are a nutrient sink that impairs humoral immunity to malaria

Rahul Vijay, Jenna J Guthmiller, Alexandria J Sturtz, Fionna A Surette, Kai J Rogers, Ramakrishna R Sompallae, Fengyin Li, Rosemary L Pope, Jo-Anne Chan, Fabian de Labastida Rivera, Dean Andrew, Lachlan Webb, Wendy J Maury, Hai-Hui Xue, Christian R Engwerda, James S McCarthy, Michelle J Boyle, Noah S Butler

2020-05-18

Plasmodium parasite–specific antibodies are critical for protection against malaria, yet the development of long-lived and effecti..

Early Endothelial Activation Precedes Glycocalyx Degradation and Microvascular Dysfunction in Experimentally Induced Plasmodium falciparum and Plasmodium vivax Infection

John Woodford, Tsin W Yeo, Kim A Piera, Kristy Butler, J Brice Weinberg, James S McCarthy, Nicholas M Anstey, Bridget E Barber

2020-05-01

Endothelial activation and microvascular dysfunction are key pathogenic processes in severe malaria. We evaluated the early role o..

Malaria Parasite Clearance: What Are We Really Measuring?

DS Khoury, SG Zaloumis, MJ Grigg, A Haque, MP Davenport, D Cromer, M Rebelo, P Cao, JM McCaw, JA Simpson, JA Flegg, DW Wilson, NM Anstey, JS McCarthy

2020-05-01

Antimalarial drugs are vital for treating malaria and controlling transmission. Measuring drug efficacy in the field requires larg..

An Experimental Human Blood-Stage Model for Studying Plasmodium malariae Infection

John Woodford, Katharine A Collins, Anand Odedra, Claire Wang, Ihn Kyung Jang, Gonzalo J Domingo, Rebecca Watts, Louise Marquart, Matthew Berriman, Thomas D Otto, James S McCarthy

2020-03-15

Background Plasmodium malariae is considered a minor malaria parasite, although its global disease burden is underappreciated. The..

Type I Interferons Suppress Anti-parasitic Immunity and Can Be Targeted to Improve Treatment of Visceral Leishmaniasis

R Kumar, PT Bunn, SS Singh, SS Ng, M Montes de Oca, F De Labastida Rivera, SB Chauhan, N Singh, RJ Faleiro, CL Edwards, TCM Frame, M Sheel, RJ Austin, SW Lane, T Bald, MJ Smyth, GR Hill, SE Best, A Haque, D Corvino

2020-02-25

CD4⁺ T cells are critical for control of intracellular parasites such as Leishmania donovani. Kumar et al. show that ty..

Poly(amino acids) as a potent self-adjuvanting delivery system for peptide-based nanovaccines

M Skwarczynski, G Zhao, JC Boer, V Ozberk, A Azuar, JG Cruz, AK Giddam, ZG Khalil, M Pandey, MA Shibu, WM Hussein, RJ Nevagi, MR Batzloff, JW Wells, RJ Capon, M Plebanski, MF Good, I Toth

2020-01-29

To be optimally effective, peptide-based vaccines need to be administered with adjuvants. Many currently available adjuvants are t..

Transcriptional profiling and immunophenotyping show sustained activation of blood monocytes in subpatentPlasmodium falciparuminfection

Jessica R Loughland, Tonia Woodberry, Matt Field, Dean W Andrew, Arya SheelaNair, Nicholas L Dooley, Kim A Piera, Fiona H Amante, Enny Kenangalem, Ric N Price, Christian R Engwerda, Nicholas M Anstey, James S McCarthy, Michelle J Boyle, Gabriela Minigo

2020-01-01

Objectives Malaria, caused by Plasmodium infection, remains a major global health problem. Monocytes are integral to the immune re..

Safety and effectiveness of apheresis in the treatment of infectious diseases: A systematic review

A Odedra, DG Lalloo, G Kennedy, S Llewellyn, JS McCarthy

2019-12-01

Objectives: Apheresis has been used as adjunctive treatment of severe falciparum malaria, loiasis and babesiosis. This systematic ..

Loss of complement regulatory proteins on red blood cells in mild malarial anaemia and in Plasmodium falciparum induced blood-stage infection

DA Oyong, JR Loughland, A Sheelanair, D Andrew, FDL Rivera, KA Piera, T William, MJ Grigg, BE Barber, A Haque, CR Engwerda, JS McCarthy, NM Anstey, MJ Boyle

2019-09-18

Background: Anaemia is a major consequence of malaria, caused by the removal of both infected and uninfected red blood cells (RBCs..

Metabolomic profiling of the excretory–secretory products of hookworm and whipworm

P Wangchuk, K Kouremenos, RM Eichenberger, M Pearson, A Susianto, DS Wishart, MJ McConville, A Loukas

2019-07-01

Introduction: Soil-transmitted helminths infect billions of people, livestock and companion animals worldwide, and chronic infecti..

Malaria morbidity and mortality following introduction of a universal policy of artemisinin-based treatment for malaria in papua, indonesia: A longitudinal surveillance study

E Kenangalem, JR Poespoprodjo, NM Douglas, FH Burdam, K Gdeumana, F Chalfein, null Prayoga, F Thio, A Devine, J Marfurt, G Waramori, S Yeung, R Noviyanti, P Penttinen, MJ Bangs, P Sugiarto, JA Simpson, Y Soenarto, NM Anstey, RN Price

2019-05-01

Background Malaria control activities can have a disproportionately greater impact on Plasmodium falciparum than on P. vivax in ar..

Challenges and strategies for developing efficacious and long-lasting malaria vaccines

JG Beeson, L Kurtovic, C Dobaño, DH Opi, JA Chan, G Feng, MF Good, L Reiling, MJ Boyle

2019-01-09

Although there has been major recent progress in malaria vaccine development, substantial challenges remain for achieving highly e..

Cell-Penetrating Peptides: Efficient Vectors for Vaccine Delivery

Jieru Yang, Yacheng Luo, Mohini Anjna Shibu, Istvan Toth, Mariusz Skwarczynski

2019-01-01

Subunit vaccines are composed of pathogen fragments that, on their own, are generally poorly immunogenic. Therefore, the incorpora..

Assessing Plasmodium falciparum transmission in mosquito-feeding assays using quantitative PCR

CYT Wang, JS McCarthy, WJ Stone, T Bousema, KA Collins, S Bialasiewicz

2018-07-05

Background: Evaluating the efficacy of transmission-blocking interventions relies on mosquito-feeding assays, with transmission ty..

A controlled human malaria infection model enabling evaluation of transmission-blocking interventions

KA Collins, CYT Wang, M Adams, H Mitchell, M Rampton, S Elliott, IJ Reuling, T Bousema, R Sauerwein, S Chalon, JJ Möhrle, JS McCarthy

2018-04-02

BACKGROUND. Drugs and vaccines that can interrupt the transmission of Plasmodium falciparum will be important for malaria control ..